Sulfur and silicon-containing fatty acid amides

Details Sulfur and silicon-containing fatty acid amides Sulfur and silicon-containing fatty acid amides

1982-09-29

1984-02-28

Shaver, Paul F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

556419, 548406, C07F 710

Patent

active

044341610

ABSTRACT:
Sulfur and silicon-containing amides, e.g. N-5-sila-3-thia-5,5-dimethyl-pentadecanoyl-1-phenyl-2-(4-methylphenyl)-eth ylamine, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl phenyl, tryptophanyl, benzocycloalkyl-type) with a corresponding sulfur and silicon-containing carboxylic acid (or active form thereof).

REFERENCES:
patent: 3660454 (1972-05-01), Gornowicz et al.
patent: 3812164 (1974-05-01), Schulz
patent: 4297349 (1981-10-01), Barcza
patent: 4328216 (1982-05-01), Toyoshima et al.
"Artery", 5, No. 3, pp. 222-236, (1979).
"Experimental and Molecular Pathology", 18, pp. 162-176, (1973).
"Science", 180, pp. 1332-1339, (1973).

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