Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-08-07
1998-10-06
Eisenschenk, Frank C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 914, 4353201, 435325, 4352521, 536 232, 536 235, C12P 2106, C12N 1564
Patent
active
058174796
ABSTRACT:
The present invention provides polynucleotides (kin) which identify and encode novel protein kinases (KIN) expressed in various human cells and tissues. The present invention also provides for antisense sequences and oligonucleotides designed from the nucleotide sequences or their complements. The invention further provides genetically engineered expression vectors and host cells for the production of purified KIN peptides, antibodies capable of binding KIN, and inhibitors specifically bind KIN. The invention specifically provides for diagnostic kits and assays which identify a disorder or disease with altered kinase expression and allow monitoring of patients during drug therapy. These assays utilize oligonucleotides or antibodies produced using the kin polynucleotides.
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Au-Young Janice
Bandman Olga
Hawkins Phillip R.
Wilde Craig G.
Billings Lucy J.
Eisenschenk Frank C.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Nolan Patrick J.
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