Method for the preparation of 1,3-disubstituted 4,5-cis-dicarbox

Details Method for the preparation of 1,3-disubstituted 4,5-cis-dicarbox Method for the preparation of 1,3-disubstituted 4,5-cis-dicarbox

1982-12-16

1987-04-21

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23332

Patent

active

046598375

ABSTRACT:
A process for the preparation of 1,3-disubstituted 4,5-cis-dicarboxy-2-imidazolidones useful as intermediates in the preparation of Vitamin H (biotin), said intermediates have the general formula ##STR1## in which R is an aliphatic hydrocarbon radical having 1 to 8 carbon atoms, an aralkyl radical or an aromatic hydrocarbon radical, preferably an allyl radical or a benzyl radical, comprising reacting a defined diaminosuccinic acid with phosgene in the presence of an alkali metal hydroxide.

REFERENCES:
patent: 2489232 (1949-11-01), Goldberg et al.
patent: 2534332 (1950-12-01), Woodward
Bedel, C., Comptes Rendus, 177, 168-171 (1925).
Boon, W., J. Chem. Soc., 307 (1947).
Lob, G., Rec. Trav. Chim., 55, 859 (1936).
Fieser, M., et al., Reagents for Organic Synthesis, vol. 2, Wiley-Interscience, New York, 1969, p. 455.

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