Sulfur-substituted diphenyl ethers having antiviral activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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Details

260465F, 564 85, 564 83, 514522, 514601, A01N 3734, C07C12150, C07C14378, C07C14374

Patent

active

045059292

ABSTRACT:
Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: ##STR1## wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R.sub.1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R.sub.2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3 and R.sub.4 represents cyano or dialkylamino; R.sub.3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3; and R.sub.4 represents cyano or dialkylamino; or alternatively R.sub.2 and R.sub.3 taken together represent the radical --O--C(X).sub.2 --O-- wherein X represents hydrogen, bromo, chloro or fluoro.

REFERENCES:
patent: 3766238 (1973-10-01), Rohr
patent: 3813444 (1974-05-01), Abe et al.
patent: 4091109 (1978-05-01), Aoki et al.
Gites et al., Chemical Abstracts, vol. 67:116462q (1967).

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