Novel 4,5-Bis (4-methoxyphenyl)-2-(pyrrol-2-yl) thiazoles and ph

Details Novel 4,5-Bis (4-methoxyphenyl)-2-(pyrrol-2-yl) thiazoles and ph Novel 4,5-Bis (4-methoxyphenyl)-2-(pyrrol-2-yl) thiazoles and ph

1985-04-12

1987-04-21

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548205, A61K 31425, C07D27724, C07D27728

Patent

active

046597263

ABSTRACT:
Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)-thiazoles of the formula: ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, 2,2,2-trifluoroethyl, a group of the formula: --CH.sub.2 COOR.sup.2 R.sup.2 is C.sub.1-8 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, or phenyl-C.sub.1-2 alkyl), or a group of the formula: --(CH.sub.2).sub.n --A--R.sup.3 (A is oxygen or sulfur, R.sup.3 is C.sub.1-4 alkyl or C.sub.2-4 alkenyl, and n is 1, 2 or 3), a process for the preparation of the compounds, and a pharmaceutical composition useful as a platelet aggregation inhibitor which comprises as an active ingredient the above 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole compound in admixture with a conventional pharmaceutically acceptable carrier or diluent.

REFERENCES:
patent: 4168315 (1979-09-01), Rynbrandt et al.
patent: 4322428 (1982-03-01), Matsumoto et al.
patent: 4466976 (1984-08-01), Klose et al.
Rynbrandt et al., J. Med. Chem., vol. 24, pp. 1507-1510, 1981.

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