2,6-Diamino-1,4-dihydropyridine derivatives

Details 2,6-Diamino-1,4-dihydropyridine derivatives 2,6-Diamino-1,4-dihydropyridine derivatives

1974-03-27

1976-04-13

Gallagher, Richard J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260287R, 260290H, 26029367, 26029368, 26029369, 26029373, 26029375, 26029378, 2602938, 26029381, 2602948G, 2602949, 2602955A, 2602955R, 424251, 424258, 424263, C07D23934

Patent

active

039503364

ABSTRACT:
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

REFERENCES:
patent: 3511837 (1970-05-01), Bossert et al.

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