Pyrimidofuroxans, their preparation and their use

Details Pyrimidofuroxans, their preparation and their use Pyrimidofuroxans, their preparation and their use

1993-05-25

1995-01-17

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514258, 544118, 544254, A61K 31495, A61K 3150, C07D41300, C07D41302

Patent

active

053825853

ABSTRACT:
The present invention relates to pyrimidofuroxans of the general formula I ##STR1## in which A denotes ##STR2## where in each case the nitrogen atom is bonded via the C-4 and the carbon atom via the C-3 of the furoxan ring and the R radicals are defined as indicated in Claim 1, processes for their preparation and their use for the control and prevention of disorders of the cardiovascular system, in particular for the control and prevention of angina pectoris, and for the treatment of erectile dysfunctions.

REFERENCES:
patent: 4356178 (1982-10-01), Schonafinger et al.
patent: 4416893 (1983-11-01), Schonafinger et al.
Yoneda et al., Journal of Heterocyclic Chemistry, 10(3), 415, Jun. 1973.
Yoneda et al., Heterocycles, 15(1), 341-344, 1981.
Arzneim.-Forschung/Drug Res. 33(I), Nr. 6 (1983), p. 803, Binder et al.
J. Chem. Soc. Parkin Trans I (1976), p. 1327, Nutiu et al.
J. Org. Chem. 1986, p. 2086, Temple et al.
J. Chem. Soc., Chem. Commun., 1982, pp. 267 and 60, Tennant et al.
Heterocycles, vol. 5, No. 2, 1975, pp. 113-116, Yoneda et al.
J. Het. Chem. 1973, p. 993.

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