Process for the production of 2.beta.-formyl 3.alpha.-protected

Details Process for the production of 2.beta.-formyl 3.alpha.-protected Process for the production of 2.beta.-formyl 3.alpha.-protected

1973-08-28

1976-01-13

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603458, 2604488R, 260468D, 260514D, C07F 718, C07D30906

Patent

active

039324672

ABSTRACT:
2-Formyl-3-protected hydroxy-5-oxocyclopent-1-eneheptanoic acid and its esters are stereoselectively reduced to the corresponding 2.beta.-formyl-3.alpha.-protected hydroxy-5-oxocyclopentane-1.alpha.-heptanoic acid and esters with chromous sulfate. The compounds so produced are useful as intermediates to PGE.sub.1 and its esters, which compounds exhibit hypotensive and smooth muscle-stimulating properties.

REFERENCES:
patent: 3532721 (1970-10-01), Finch
Organic Syntheses 49, p. 102 (1969).
Miyano et al., Chem. Comm. 180 (1973).
Finch et al. Tet. Letters, 4639 (1969).

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