Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-02-08
1995-01-17
Parr, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4, 435 18, 435 23, 435 24, 436501, 436518, 436524, 436528, 436531, 436 86, 436 89, 436 90, 530350, 5303871, C12Q 100, G01N 33566, G01N 33543, C07K 300
Patent
active
053825136
ABSTRACT:
The instant invention provides a library of bio-oligomers of defined size and known composition, in which the library contains all of the possible sequences of the bio-oligomers, and a method of synthesis thereof. The bio-oligomers of the library may be peptides, nucleic acids, or a combination of the foregoing. The instant invention also provides methods to identify bio-oligomers from a library that demonstrate desired characteristics such as binding, bioactivity and catalytic activity. Thus the instant invention provides a unique and powerful method to identify a useful bio-oligomer sequences from a library more quickly than current state-of-the-art technology allows. Effector molecules for use in treatment or diagnosis of disease are also provided.
REFERENCES:
patent: 4392997 (1983-07-01), Goldberg
patent: 4555101 (1985-11-01), Hopp
patent: 4590003 (1986-05-01), Twardzik et al.
patent: 4618598 (1986-10-01), Conn
patent: 4625014 (1986-11-01), Senter et al.
patent: 4631211 (1986-12-01), Houghten
patent: 4703008 (1987-10-01), Lin
patent: 4705777 (1987-11-01), Lehrer
patent: 4780421 (1988-10-01), Kameda et al.
patent: 4798787 (1989-01-01), McCormic et al.
patent: 4833072 (1989-05-01), Krchnak et al.
patent: 4833092 (1989-05-01), Geysen
patent: 4837304 (1989-06-01), Gersky et al.
patent: 4863857 (1989-09-01), Blalock
patent: 4988625 (1991-01-01), Marburg et al.
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5182366 (1993-01-01), Huebner et al.
patent: 5194392 (1993-03-01), Geysen
Furka et al., 1988, "Cornucopia of peptides by synthesis," 14th International Congress of Biochemistry, vol. 5, Abstract FR:013.
Geysen et al, 1984, "Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid," Proc. Nat. Acad. Sci. U.S.A. 81:3998-4002.
Geysen et al., 1985, "Antigen-antibody interactions at the molecular level: adventures in peptide synthesis," Immunol. Today 6:364-369.
Geysen et al., 1986, "A priori delineation of a peptide which mimics a discontinous antigenic determinant," Mol. Immunol., 102:709-715.
Geysen et al., 1986, "The delineation of peptides able to mimic assembled epitopes," Synthetic peptides as antigens, CIBA Foundation Symposium 119, Wiley, Chichester, pp. 130-149.
Geysen et al., 1987, "Strategies for epitope analysis using peptide synthesis," J. Immunol. Meth. 102:259-274.
Geysen et al., 1988, "A synthetic strategy for epitope mapping," in Peptides, Chemistry and Biology, Proceedings of the Tenth American Peptide Symposium, Marshal, Ed., Escom, Leiden pp. 519-523.
Houghten, 1985, "General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids," Proc. Natl. Acad. Sci. U.S.A. 82:5131-5135.
Krchnak et al., 1989, "Multiple continuous-flow solid-phase peptide synthesis," Int. J. Peptide Protein Res., 33:209-213.
Berg et al., 1989, "Long-chain polystyrene-grafted polyethylene film matrix: A new support for solid-phase peptide synthesis," J. Am. Chem. Soc., 111:8024-8026.
Merrifield, 1985, "Solid phase synthesis (Nobel Lecture)," Angewandte Chemie 24(10):799-810.
Kauvar et al., 1990, "Paralog chromatography," BioTechniques 8(2):204-209.
Kennedy et al., 1987, "Use of resin-bound synthetic peptide for identifying a neutralizing antigenic determinant associated with the human immunodeficiency virus envelope," J. Biol. Chem., 262(12):5769-5774.
Syu and Kahan, 1989, "Epitope characterization by modifications of antigens and by mapping on resin-bound peptides," J. Immunol. Methods 118:153-160.
Zee et al., 1989, "Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides," Eur. J. Immunol., 19:43-47.
Bost and Blalock, 1989, "Preparation and use of complementary peptides," Meth. Enzym. 168:16-28.
Bost et al., 1985, "Similarity between the corticotropin (ACTH) receptor and a peptide encoded by an RNA that is complementary to ACTH mRNA," Proc. Natl. Acad. Sci. U.S.A. 82:1372-1375.
Blalock and Bost, 1986, "Binding of peptides that are specified by complementary RNAs," Biochem J. 234:679-683.
Lebl and Elchler, 1989, "Simulation of continuous solid phase synthesis: Synthesis of methionine enkephalin and its analogs," Peptide Res., 2(4):297-300.
Furka et al., 1991, "General method for rapid synthesis of multicomponent peptide mixtures," Int. J. Peptide Protein Res., 37:487-493.
Wade et al., 1990, "All-D amino acid-containing channel-forming antibiotic peptides," Proc. Natl. Acad. Sci. USA 87:4761-4765.
Baum, 1991, "Technique offers parallel synthesis of thousands of chemical compounds," C&EN, Feb. 25, 199, pp. 21-22.
Fodor et al., 1991, "Light-directed, spatially addressable parallel chemical synthesis," Science 251:767-773.
McCafferty et al., 1990, "Phage antibodies: Filamentous phage displaying antibody variable domains," Nature 348:552-554.
Blackwell and Weintraub, 1990, "Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection," Science 250:1104-1110.
Beardsley, 1990, "New order: Artificial evolution creates proteins nature missed," Scientific American, Oct. 1990, 18-24.
Green et al., 1990, "In vitro genetic analysis of the tetrahymena self-splicing intron," Nature 347:406-408.
Ellington and Szostak, 1990, "In vitro selection of RNA molecules that bind specific ligands," Nature 346:818-822.
Cwirla et al., 1990, "Peptides on phage: A vast library of peptides of peptides for identifying ligands," Proc. Natl. Acad. Sci. USA:87:6378-6382.
Abelson, 1990, "Directed evolution of nucleic acids by independent replication and selection," Science 249:488-489.
Turek and Gold, 1990, "Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase," Science 249:505-510.
Devlin et al., 1990, "Random peptide libraries: A source of specific binding protein molecules," Science 249:404-406.
Scott and Smith, 1990, "Searching for peptide ligands with an epitope library," Science 249:386-390.
Parmley and Smith, 1988, "Antibody-selectable filamentous Fd phage vectors: Affinity purification of target genes," Gene 73:305-318.
Rand et al., 1989, "Cloning and expression of a protective antigen from the cattle tick Boophilus-microplus," Proc. Natl. Acad. Sci. USA 86:9657-9661 (Abstract Only).
Lu et al., 1988, "Synthesis and anti Candida-ablicans activity of L-4 oxalysine-containing oligopeptides," Acta Pharm. Sin., 23(7):504-510 (Abstract Only).
Brooks et al., 1988, "SK&F 105494 is a potent antidiuretic hormone antagonist in the rhesus monkey (Macaca mulatta)," J. Pharmacol. Exp. Ther., 245:211-215 (Abstract Only).
Breslow et al., 1988, "Optically active amino acid synthesis by artificial transaminase enzymes," Tetrahedron 44(17):5515-5524 (Abstract Only).
Lam Kit S.
Salmon Sydney E.
Bioligand Inc.
Parr Margaret
Sisson Bradley Lounsbury
LandOfFree
Method of screening a peptide library does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of screening a peptide library, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of screening a peptide library will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-746696