Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin

Details Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin Process for preparing 6-chloro-2-chloromethyl-4-phenylquinazolin

1974-09-23

1976-01-13

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260562B, 260566D, C07D23976

Patent

active

039323250

ABSTRACT:
A process is described for the preparation of 6-chloro-2-chloromethyl-4-phenylquinazoline-3-oxide, a key intermediate in the synthesis of the known useful psychotherapeutic agents: chlorodiazepoxide and diazepam. This intermediate is prepared by the cyclization of 2-(1'-chloroimino-2'-chloromethyl)-5-chlorobenzophenone, itself a new compound. This compound in turn is prepared by the chloroacetylation of 2-amino-5-chlorobenzophenone to 2-chloroacetamido-5-chlorobenzophenone, another novel compound, and subsequent iminochloride formation.

REFERENCES:
patent: 3340253 (1967-09-01), Reeder et al.

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