26,26,26,27,27,27-Hexafluoro-1.alpha.,25-dihydroxycholecalcifero

Details 26,26,26,27,27,27-Hexafluoro-1.alpha.,25-dihydroxycholecalcifero 26,26,26,27,27,27-Hexafluoro-1.alpha.,25-dihydroxycholecalcifero

1981-07-27

1982-11-09

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603972, 560256, 568819, C07J 1700, C07C 3521, C07C 69013

Patent

active

043584063

ABSTRACT:
This invention provides a new derivative of vitamin D, 26,26,26,27,27,27-hexafluoro-1.alpha.,25-dihydroxycholecalciferol, a process for preparing the same, and novel intermediate compounds.
The compound is characterized by vitamin D-like activity substantially greater than that exhibited by 1.alpha.,25-dihydroxycholecalciferol which is considered to be the active hormonal form of vitamin D. The compound would find ready application as a substitute for vitamin D and in the treatment of or prophylaxis for disease states evincing metabolic calcium and phosphorous deficiences or imbalances.

REFERENCES:
patent: 4226788 (1980-10-01), DeLuca et al.
patent: 4248791 (1981-02-01), DeLuca et al.

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