Method of using 4-amino-.DELTA..sup.4 -steroids in the treatment

Details Method of using 4-amino-.DELTA..sup.4 -steroids in the treatment Method of using 4-amino-.DELTA..sup.4 -steroids in the treatment

1994-02-25

1995-07-25

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514176, C07J 300, C07J 500

Patent

active

054362377

ABSTRACT:
The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.

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Drugs of the Future 1994, 19(7): 646-650; Steroid 5.alpha.-Reductase Inhibitor Treatment for Benign Prostatic Hyperplasia.
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Derwent Basic Abstract 11,765 (JP 4476/64), 1964.
R. D. Lynch, "Synthesis and Chemistry of Steroidal Azido Ketones. Possible Photoaffinity Labels of Steroids Receptor Proteins," Ph.D. Dissertation (Vanderbilt University), Dec. 1977, pp. XIV, XV, 22, 26, 40, 41, 42, 95, and 96 Dec. 1, 1981.
Zlobino M., Chemical Abstracts, vol. 106, No. 21, dated May 25, 1987. Abstract No. 176726.

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