Human intra-acrosomal sperm antigen

Details Human intra-acrosomal sperm antigen Human intra-acrosomal sperm antigen

1990-02-16

1995-07-25

Kim, Kay K. A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 691, 435 693, 4352523, 4353201, 536 235, 530852, 4241851, 424811, C12N 1512, C12N 1570

Patent

active

054361575

ABSTRACT:
A substantially purified intra-acrosomal human sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with human sperm after the acrosome reaction. In particular, it remains associated with the inner and outer acrosomal membranes. Modified antigens and fragments thereof prepared by protein modification techniques are also disclosed as well as methods for purifying and using the antigens. Also disclosed are monoclonal and polyclonal antibodies to the antigen and methods of making and using such antibodies. Methods of use include purification of the antigen or use in various diagnostic techniques. Also disclosed are cDNA, expression vectors, and transformed microorganisms that produce the antigen.

REFERENCES:
patent: 4741998 (1988-05-01), Herr et al.
patent: 4782136 (1988-11-01), Goldberg et al.
patent: 5047508 (1991-09-01), Herr et al.
Akekunle et al (1989) Biol. Reprod., 40:127-134.
Doege et al (1987) JBC 262(36):17757-17767.
Millan et al. (1987) PNAS USA 84:5311-5315.
Young et al (1983) PNAS USA 80:1194-1196.
Yi et al (1991) Biol. Reprod. 44:332-337.
Cowan et al (1986) J. Cell Biol. 103:1289-1297.
Hardy et al (1988) Biology of Reproduction 38:423-437.
Herr et al (1990) Biology of Reproduction 42:181-193.
Lee et al (1986) J. Reprod. Immunol. 9:261-274.
Liu et al (1989) Int. J. Andrology 12:451-463.
Anderson et al., Journal of Reproductive Immunology, 10:231-257 (1987).
Herr et al., J. Andrology, 9:42 (1988), 13th Ann. Meet. Abst. #96.
Kallajoki et al., International Journal of Andrology, 7:283-296 (1984).
Kallajoki et al., International Journal of Andrology, 9:181-194 (1986).
Salonen et al., International Journal of Andrology, 10:731-739 (1987).
Kallajoki et al., Biology of Reproduction, 35:157-165 (1986).
Lee et al., J. Reproductive Immunology, 4:173-181 (1982).
Huneau et al., International Journal of Andrology, 11:13-24 (1987).
Primakoff et al., Nature, 335:543-546 (1988).
Herr et al., Journal of Forensic Sciences, 32:346-356 (1987).
Herr et al., Biology of Reproduction, 35:773-784 (1986).
Maruyama et al., Journal of Andrology, 6:127-135 (1985).
Wolff et al., Fertility and Sterility, 49:497-504 (1988).
Marx, Science, 240:1616-1618 (1988).
Moss, ABA Journal, pp. 66-70 (May 1988).
Gaensslen, "Identification of Semen and Vaginal Secretions," Sourcebook in Forensic Serology, Immunology, and Biochemistry, 149-181 (1983).
Comhaire et al., "The Significance of Semen Analysis for the Evaluation of Male Fertility," in Male Fertility: Diagnosis and Management, pp. 34-47 (Date Unknown).
Wolf et al., Biology of Reproduction, 29:713-723 (1983).
Isojima et al., Journal of Reproductive Immunology, 10:67-78 (1987).
Yan et al., American Journal of Reproductive Immunology, 4:111-115 (1983).
Paul et al., Clinical Reproduction and Fertility, 1:235-240 (1982).
Hancock et al., Journal of Reproductive Immunology, 7:215-223 (1985).
Kyurkchiev et al., Immunology, 57:489-492 (1986).
Isojima et al., Clin. Exp. Immunol., 49:449-456 (1982).
Isojima et al., Immunological Approaches to Contraception and Promotion of Fertility, (Talwar Ed.), 323-333 (Plenum Publishing, 1986).
Chang et al., Science, 240:324-326 (1988).
Anderson et al., Fertility and Sterlity, 40:557-571 (1983).
Naz, Journal of Reproductive Immunology, 11:117-133 (1987).
Yanagimachi, "Mammalian Fertilization," in The Physiology of Reproduction, (Knobil et al. Eds.), pp. 135-185 (Raven Press 1988).
Nagae et al., Fertility and Sterlity, 45:701-707 (1986).
Yudin et al., Gamete Research, 20:11-24 (1988).
Cross et al., Gamete Research, 15:213-226 (1986).
Abstract No. 225934, Anderson et al., Journal of Reproductive Immunology, 10:231-257 (1987).
Biological Abstracts, vol. 79(5) Abstract No. 44868, Kallajoki et al., International Journal of Andrology, 7:283-296 (1984).
Gould et al., Developmental Biology, 117:306-318 (1986).
Biological Abstracts, vol. 89, Abstract No. 120800, Herr et al., Biol. Reprod, 42:181-194 (1990).
Biological Abstracts, vol. 86(7), Abstract No. 75251, Yudin et al., Gamete Res., 20:11-24 (1988).
Biological Abstracts, vol. 84(12), Abstract No. 124183, Mortimer et al., Reprod. Fertil., 81:127-136 (1987).
Biological Abstracts, vol. 77(5), Abstract No. 39354, Working et al., J. Exp. Zool., 227:97-108 (1983).
Noland et al., J. Biological Chemistry, 264:13586-13590 (1989).
Sofer et al., BioTechniques, pp. 198-203 (Nov./Dec. 1983).
PCT Search Report dated Jul. 26, 1990.
Wright et al., Biol. Reproduction, 42:693-701 (1990).
Baba et al., FEBS Letters, 244:296-300 (1989).

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