Trifluoromethylthio derivatives of cyproheptadine

Details Trifluoromethylthio derivatives of cyproheptadine Trifluoromethylthio derivatives of cyproheptadine

1975-12-22

1977-06-21

Jaisle, Cecilia M. S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

26029362, C07D21170

Patent

active

040312232

ABSTRACT:
Cyproheptadine derivatives substituted with a trifluoromethylthio group in one of the benzo rings and certain derivatives thereof are potent antipsychotic agents, with a low propensity to induce extrapyramidal side effects experienced with most major tranquilizers, and platelet aggregation inhibitors useful as antithrombotic agents. The antipsychotic activity resides in the levorotatory enantiomer whereas both enantiomers are platelet aggregation inhibitors. The novel compounds are prepared by treatment of the corresponding iodo compound with trifluoromethylthiocopper formed from bis-(trifluoromethylthio)mercury and copper powder.

REFERENCES:
patent: 3851059 (1974-11-01), Prugh
Ebnother et al., Helv. Chim. Acta 48(6), 1237-1249 (1965).
Yagupolskii et al., Synthesis, 721 (1975).

Affiliated with

Also associated with

Rating

Trifluoromethylthio derivatives of cyproheptadine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Trifluoromethylthio derivatives of cyproheptadine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trifluoromethylthio derivatives of cyproheptadine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-736894