Complexes of glycerrhetinic acid with phospholipids and pharmace

Details Complexes of glycerrhetinic acid with phospholipids and pharmace Complexes of glycerrhetinic acid with phospholipids and pharmace

1991-01-15

1992-09-15

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514143, 514177, 536 5, 536 62, 424450, 554 80, A61K 31705, A61K 31575, A61K 9127

Patent

active

051478595

ABSTRACT:
Complexes of glycyrrhetinic acid with phospholipids are described in which the molar ratio of phospholipids to glycyrrhetinic acid is from 0.5 to 2. The phospholipids are selected from the group consisting of soy lecithins, phospholipids from bovine or swine brain or cutis, phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine in which the acyl groups can be the same or different and are mostly derived from palmitic, stearic, oleic, linoleic, linolenic acids. The phospholipid may be soy phosphatidylcholine or distearoylphosphatidylcholine. Pharmaceutical compositions and a method for producing anti-inflammatory, antiulcer and healing effects in an animal are also described.

REFERENCES:
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Yu et al.; Chemical Abstracts 106:23158d (1987).
Proserpio; Chemical Abstracts 110:141220y (1989).
Takendouchi et al.; Chemical Abstracts 111:140222; (1989).
Tsuji et al.; Chem. Pharm. Bull. 39(4):1004-1008 (1991).

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