Conjugates of VIP and active fragments thereof with hydrophobic

Details Conjugates of VIP and active fragments thereof with hydrophobic Conjugates of VIP and active fragments thereof with hydrophobic

1989-07-07

1992-09-15

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 530324, 530327, C07K 710, C07K 708, A61K 3702

Patent

active

051478552

ABSTRACT:
There are provided pharmaceutical compositions for topical transdermal application for the treatment of male impotence. The active ingredients of such compositions are selected from vasoactive intestinal peptide (VIP), effective derivatives thereof and effective fragments thereof. In the compositions for the treatment of male impotence a transdermally effective conjugate of VIP, its derivatives or fragments coupled to a hydrophogic moiety, is used.

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Vasoactive Intestinal Polypeptide and the Reproductive System Annals of New York Academy of Sciences, 1988; 393-404; Fahrenkrug et al.
Octapeptides Deduced From the Neuropeptide Receptor-like Pattern of Antigen T4 in Brain Potently Inhibit Human Immunodeficiency . . . Infectivity, vol. 83, pp. 9254-9258 (1986); Pert et al.
Solid Phase Peptide Synthesis, vol. 85, pp. 2149-2154 R. B. Merrifield (1963).
Attenuation by a 5x-Reductase Inhibitor of the Activational Effect of Testosterone Propionate on Penile Erections in Castrated Male Rats, vol. 109, No. 4, pp. 1047-1051 (1981), Bradshaw et al.
Effects of Chronic Hyperprolactinemia on Sexual Arousal and Erectile Function in Male Rats Neuroendocrinology 42:368-375 (1986), Doherthy et al.
Jan Fahrenkrug et al., Vasoactive Intestinal Polypeptide and the Reproductive System, 1988, Annals of New York Academy of Sciences, (393-404).

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