Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1999-08-30
2000-03-21
Brusca, John S.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 435 701, 435 703, 536 231, 536 235, C07K 1400, C12N 1500, C12P 2100, C07H 2104
Patent
active
060404299
ABSTRACT:
In accordance with the present invention, there are provided novel Congenital Heart Disease (CHD) proteins. Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention CHD proteins can be employed in a variety of ways, for example, for the production of anti-CHD antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies.
REFERENCES:
patent: 5346815 (1994-09-01), Krulwich et al.
patent: 5869318 (1999-02-01), Palleja et al.
patent: 5935783 (1999-08-01), Gong et al.
Antonarakis et al., 1989, "Molecular Mapping of Chromosome 21 and the region responsible for Down Syndrome", Molecular and Cytogenetic Studies of Non-Disjunction, 29-43.
Chumakov et al., 1992, "Continuum of overlapping clones spanning the entire human chromosome 21q" Nature 359:380-87.
Cohen et al., 1993, "A first-generation physical map of the human genome", Nature 366:698-701.
Doolittle, 1986, Of URFS and ORFS, A Primer on How to Analyze Derived Amino Acid Sequences, University Science Books, Mill Valley CA, p. 7.
Hillier et al., 1995, "Homo sapiens cDNA clone 251486 3'", The WashU-Merck EST Project, ID #HS008249.
Hillier et al., 1995, WashU-Merck EST Project, ID No.:H98008.
Hubert et al., 1995, "Down Syndrome congenital heart disease: Physical and Transcriptional mapping of the candidate region using BACs and PACs", Am. J. Hum. Gen., 57(4):A13.
Ioannou et al., 1994, "A new bacteriophage P1-derived vector for the propagation of large human DNA fragments", Nature Genetics 6:84-89.
Julie R. Korenberg, 1993, "Toward A Molecular Understanding of Down Syndrome", The Phenotypic Mapping of Down Syndrome and Other Aneuploid Conditions, 87-115.
Korenberg et al., 1995, "A High Fidelity Physical Map of Human Chromosome 21q in Yeast Artificial Chromosomes", Genome Research 5:427-443.
Korenberg et al., 1994 "Down syndrome phenotypes: The consequences of chromosomal imbalance", Proc. Natl. Acad. Sci. USA 91:4997-5001.
Korenberg et al., 1992, "Down Syndrome: Molecular Mapping of the Congenital Heart Disease and Duodenal Stenosis", Am. J. Hum. Genet. 50:294-302.
Korenberg and Chen, 1995, "Human cDNA mapping using a high-resolution R-banding technique and fluorescence in situ hybridization", Cytogenet Cell Genet. 69:196-200.
Marra et al., 1996, WashU-HHMI Mouse EST Project, ID No.: W41440.
Marra et al., 1996, "Mus Musculus cDNA clone 3511675'", The WashU-HHMI Mouse EST Project, ID #MM44015.
Marra et al., 1996, WashU-HHMI Mouse EST Project, ID No.: W53931.
Morgan et al., 1992, "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes", Nucleic Acids Research 20(19):5173-5179( ).
Osoegawa et al., 1996, "An Integrated Map with Cosmid/PAC Contigs of a Mb Down Syndrome Critical Region", Genomics 32:375-387.
Patil, N., 1994, "A high resolution physical map of 2.5 Mbp of the Down syndrome region on chromosome 21", Human Molecular Genetics 3(10):1811-1817.
Reeck et al., "`Homology` in Proteins and Nucleic Acids: A Terminology Muddle and a Way Out of It", Cell 50:667.
Shimizu et al., 1995, "Report of the Fifth International Workshop on Human Chromosome 21 Mapping 1994", Cytogenet Cell Genet., 70:147-182.
Shizuya et al., 1992, "Cloning and stable maintenance of 300-Kilobase pair fragments of human DNA in Escherichia coli using an F-factor-based vector", Proc. Natl. Acad. Sci. USA 89:8794-8797.
Turbay et al., 1996, "Molecular Cloning, Chromosomal Mapping, and Characterization of the Human Cardiac-Specific Homeobox Gene hCsx", Molecular Medicine 2(1):86-96.
Wadey et al., 1995, "Isolation of a Gene Encoding an Integral Membrane Protein from the Vicinity of a Balanced Translocation Breakpoint Associated with DiGeorge Syndrome", Human Molecular Genetics 4(6):1027-1033.
Wimmer et al., 1993, "A Drosophila homologue of human Sp1 is a head-specific segmentation gene", Nature 366:690-694.
Brusca John S.
Cedars-Sinai Medical Center
Shibuya Mark L.
LandOfFree
Congenital heart disease proteins and products related thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Congenital heart disease proteins and products related thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Congenital heart disease proteins and products related thereto will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-731374