Methods for treatment with compositions effective against acyclo

Details Methods for treatment with compositions effective against acyclo Methods for treatment with compositions effective against acyclo

1992-12-23

2000-03-21

Guzo, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 49, 536 283, 536 2852, 536 2853, 536 2854, 536 2855, A61K 3170, C07H 1700

Patent

active

060402989

ABSTRACT:
The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by herpes virus strains that are resistant to treatment with acyclovir. In particular, it has been discovered that the low dosage amounts of 1-(2'-deoxy-2'-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil (FIAU) are effective in inhibiting replication of acyclovir-resistant HSV strains. The present invention is also directed to methods of the preparation of pharmaceutical antiviral compositions and to the methods of their use in the treatment of infection or disease.

REFERENCES:
patent: 4211773 (1980-07-01), Lopez et al.
patent: 4489052 (1984-12-01), Price
patent: 4594339 (1986-06-01), Lopez et al.
patent: 4666892 (1987-05-01), Fox et al.
patent: 5010060 (1991-04-01), Laubert et al.

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