Histidyl tRNA synthetase from Streptococcus pneumoniae

Details Histidyl tRNA synthetase from Streptococcus pneumoniae Histidyl tRNA synthetase from Streptococcus pneumoniae

1998-06-08

2000-03-21

Hobbs, Lisa J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 435325, 4352523, 435440, 530324, 536 232, C12Q 168, C12N 900, C12N 1500, A61K 3800, C07H 2104

Patent

active

060401621

ABSTRACT:
The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS polypeptides to screen for antibacterial compounds.

REFERENCES:
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5) p. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) p. 322-324 (1980).
Menguito et al., "Molecular Cloning, Sequence, Structural Analysis and Expression of the Histidyl-tRNA Synthetase Gene from Streptococcus equisimilis," Nucleic Acids Research, 21(3) p. 615-620 (1993).
Von Der Haar et al., "Target Directed Drug Synthesis: The Aminoacyl-tRNA Synthetases as Possible Targets," Angewandte Chemie, 20(3) p. 217-223 (1981).
Meinnel et al., "Aminoacyl-tRNA Synthetases: Occurrence, Structure, and Function," In: tRNA: Structure, Biosynthesis, and Function, American Society for Microbiology, pp. 251-292 (1985).
Delorme et al., "Histidine Biosynthesis Genes in Lactococaus lactis subsp. lactis", Journal of Bacteriology, 174(20), pp. 6571-6579 (1992).
Ascension No. Z17214, Feb. 12, 1993, Menguito et al., Molecular cloning, sequence, structural analysis and expression of the histidyl-tRNA synthetase gene from Streptococcus esquisimilis.
Ascension No. 267058, Jun. 1, 1994, Menguito et al., Molecular cloning, sequence, structural analysis and expression of the histidyl-tRNA synthetase gene from Streptococcus equisimilis.

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