Process and compounds for RNA synthesis

Details Process and compounds for RNA synthesis Process and compounds for RNA synthesis

1991-07-12

1994-01-25

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2531, 536 267, 536 268, 435199, C07H 19067, C07H 19167, C07H 2102

Patent

active

052817016

ABSTRACT:
A method and compositions are provided for synthesizing polynucleotides wherein the exocyclic amino groups of 5'-O-protected-2'O-alkylsilyl-adenosine phosphoramidite and 5'-O-protected-2'-O-alkylsilylguanosine phosphoramidite monomers are protected with dialkylformamidine. In a preferred embodiment, the ribonucleoside phosphoramidite monomers are activated with ethylthiotetrazole.

REFERENCES:
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