Method of using Alpha 2-Antagonists for the Treatment of Neurode

Details Method of using Alpha 2-Antagonists for the Treatment of Neurode Method of using Alpha 2-Antagonists for the Treatment of Neurode

1992-10-08

1994-01-25

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514396, 514401, 514402, A61K 3144

Patent

active

052816079

ABSTRACT:
The treatment of neurodegenerative diseases by the stimulation of endogenous or recombinant expression in vivo of nerve growth factor in the central nervous system by administration of a therapeutically effective amount of an .alpha..sub.2 -antagonist.

REFERENCES:
patent: 5059627 (1991-10-01), Goto et al.
patent: 5102906 (1992-04-01), Nakayama et al.
Fabrazzo, E. et al., "Stimulation of Nerve Growth Factor Biosynthesis in Developing Rat Brain by Reserpine: Steriods as Potential mediators, Molecular Pharmacology," Molecular Pharmacology, 39:144-149 (1990).
Schwartz, Joan P., "Stimulation of Nerve Growth Factor mRNA Content in C6 Glioma Cells by a .beta.-Adrenergic Receptor and by Cyclic AMP," GLIA, 1:282-285 (1988).
Furukawa, Y et al., "Catecholamines increase nerve growth factor mRNA content in both mouse astroglial cells and fibroblast cells," FEBS Letters, vol. 247, No. 2:463-467 (1987).
Dal Toso, R. et al., "Beta Adrenergic and Prostaglandin Receptor Activation increases Nerve Growth Factor mRNA Content in C6-2B Rat Astrocytome Cells," The Journal Pharmacology and Experiment Therapeutics, 246(3):1190-1193 (1988).
Mocchetti, I. et al., "Regulation of nerve growth factor biosynthesis by .beta.-adrenergic receptor activation in astrocytoma cells: A potential role of c-Fos protein," Proc. Natl. Acad. Sci. USA, 86:3891-3895(1989).
Furukawa, Y. et al., "Catecholamines Induce an Increase in Nerve Growth Factor Content in the Medium of Mouse L-M Cells," The Journal of Biological Chemistry, vol. 261(13):6039-6047 (1986).
Dal Toso, R. et al., "Beta-Adrenergic Receptor Regulation of NGF-nRNA Content in Rat C6-2B Glioma Cells," Neuropharmacology, vol. 26(12):1786(1987).
Onrot et al., Medline Database, AN87116310, Feb. 1987.
Nishino et al., Chemical Abstracts, 113(9):71217p, 1990.

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