Tri-aryl ethane derivatives as PDE IV inhibitors

Details Tri-aryl ethane derivatives as PDE IV inhibitors Tri-aryl ethane derivatives as PDE IV inhibitors

Filed on

1996-12-10

Date issued

1998-01-20

Examiner

Ivy, C. Warren

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

514341, 514365, 546266, 5462727, 548203, C07D21330, C07D23364, A61K 3144, A61K 31415

Type

Patent

Status

active

Patent number

057101701

Description

ABSTRACT:
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.

REFERENCES:
patent: 4882343 (1989-11-01), Cordi
patent: 5580888 (1996-12-01), Warrellow
The Merck Index; S. Budavari (Ed.); 12th Edition: "An encyclopedia of chemicals, drugs, and biologicals" 1996, Merck Research Laboratories, Whitehouse Station, N.J. ISBN 0911910-12-3 XP002027526, See monograph 8410.
Chemical Abstracts #124:260846, 1995.
Chemical Abstracts #123:286011, 1995.
Chemical Abstracts #122:265044, 1994.
Chemical Abstracts #125:132083 by Gozzard, 1996.
Chemical Abstracts #125:158239 by Holbrook, 1996.
Chemical Abstracts #125:185440, 1996.
Chemical Abstracts #124:260848, 1995.

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