Analgesic composition for treatment of migraine headaches

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai

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5142245, 514300, 514728, 514812, 424 44, 424682, 424689, A61K 31615, A61K 31535

Patent

active

055389597

ABSTRACT:
A magnesium-containing analgesic composition used for treating migraine headaches and methods for using the same are described herein. The composition comprises an analgesic, a magnesium salt and an effervescing agent and is admixed with or dissolved in water prior to ingestion. The symptoms of migraine headache intended to be alleviated include nausea, unilateral pain, dizziness, pulsatile pain, worsening of pain by light physical activity, photophobia and phonophobia.

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B. M. Altura, "Calcium Antagonist Properties of Magnesium: Implications for Antimigraine Actions", Magnesium 4:169 (1985).
A. Mauskop et al., "Chronic Daily Headache--One Disease or Two? Diagnostic Role of Serum Ionized Magnesium", Cephalalgia 14:24 (1994).
A. Mauskop et al., "Deficiency in Serum Ionized Magnesium but not Total Magnesium in Patients with Migraines. Possible Role of ICa.sup.2+ /IMg.sup.2+ Ratio", Headache 33(3):135 (1993).
F. Facchinetti et al., "Magnesium Prophylaxis of Menstrual Migraine: Effects on Intracellular Magnesium", Headache 31(5):298 (1991).
K. Weaver, "Magnesium and Migraine", Letter to the Editor in Headache 30(2):168 (1990).

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