Apparatus for automated assay of DNA probe and method for assayi

Details Apparatus for automated assay of DNA probe and method for assayi Apparatus for automated assay of DNA probe and method for assayi

1993-12-29

1996-07-23

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352872, 422 55, 422 62, 422 63, 422 8205, 422100, 422104, 436 43, 436 48, 436 49, 436 94, 536 231, 536 243, C12Q 168, G01N 2100, G01N 3500, C12N 1500

Patent

active

055388493

ABSTRACT:
An apparatus is presented for an automated assay of a DNA probe, which is performed by hybridizing a nucleic acid in a sample with a DNA probe marked with an enzyme and optically measuring a change that occurs in the substrate by catalysis of the enzyme which is bound with the DNA probe. The DNA probe hybridizes with the nucleic acid in the sample to assay the nucleic acid in the sample. Comprising (A) a sample-reagent unit, (B) a sample-reagent dispense unit, (C) a reaction vessel transport unit, (D) a hybridization unit, (E) a B/F separation unit, and (F) a light measurement unit; also presented is a method for assaying a nucleic acid in a sample by the apparatus of the present invention. According to the measurement apparatus of the present invention, a continuous and highly precise measurement is attainable. In particular, the light-shielding structure of the light measurement unit exhibits high levels of light-shielding effect and contributes to efficient light measurement and prevention of degradation of light receiving elements.

REFERENCES:
patent: 5358691 (1994-10-01), Clark et al.
Keller et al., American Clinical Laboratory, Nov. 1988, pp. 10-15.

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