Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for

Details Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for

1986-11-12

1988-08-02

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540556, A61K 3155, A61K 31535, C07D40304, C07D40104

Patent

active

047614129

ABSTRACT:
The invention relates to benzopyrrolobenzodiazepines and quinobenzodiazepines of the formula ##STR1## where X and Y may be the same or different and each is hydrogen, halogen, CF.sub.3, lower alkyl, lower alkoxy, lower alkylthio and lower alkylsulfonyl, p and q are independently 1 or 2; R.sub.1 is hydrogen when R.sub.2 is bonded to R.sub.3 to form a --(CH.sub.2).sub.m --CH.sub.2 -- group or a --CH.dbd.CH-- group; R.sub.3 is hydrogen when R.sub.1 is bonded to R.sub.2 to form a --(CH.sub.2).sub.m --CH.sub.2 -- group or a --CH.dbd.CH-- group; m is 1 or 2; R.sub.4 is NR.sub.5 R.sub.6 wherein R.sub.5 is hydrogen or lower alkyl and R.sub.6 is hydrogen, lower alkyl or a group of the formula (CH.sub.2).sub.n NR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are lower alkyl, and n is 2 or 3, ##STR2## wherein R.sub.9 is lower alkyl, ##STR3## wherein R.sub.10 is CH.sub.2 CH.sub.2 OH, lower alkyl, phenyl, phenyl substituted by halogen, CF.sub.3, lower alkyl, lower alkoxy or lower alkylthio, benzyl, benzyl in which the phenyl group is substituted by halogen, CF.sub.3, lower alkyl, lower alkoxy or lower alkylthio or CO.sub.2 R.sub.11 wherein R.sub.11 is lower alkyl, or a pharmaceutically acceptable acid salt thereof.

REFERENCES:
patent: 4186199 (1980-01-01), Glamkowski et al.
patent: 4192874 (1980-03-01), Glamkowski et al.
patent: 4663453 (1987-05-01), Glamkowski et al.
Glamkowski et al, J. Med. Chem., 23, 1380 (1980).
Glamkowski et al, J. Med. Chem., 16, 865 (1979).

Affiliated with

Also associated with

Rating

Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzopyrrolobenzodiazepines and quinobenzodiazepines useful for will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-711962