Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase
Patent
1987-02-05
1988-08-02
Nucker, Christine M.
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
435 7, 435 8, 436500, 436537, 436800, 436805, G01N 33536, G01N 33542
Patent
active
047613823
ABSTRACT:
This invention relates to a method of detecting, analyzing, quantifying, or locating a substance of biological interest by an immunoassay in which a first component of an immune reaction in the form of an antigen, hapten, or antibody, is linked with one or more components of a chemiluminescent reaction, and the other component of the immune reaction, the analyte, is complexed therewith to cause entropic and/or ethalpic changes in a subsequent light emitting action as compared with the reaction of uncomplexed labelled component, the reaction being observed and compared to provide information on the immune complex formation. Preferably the intensity of light emission of the rate of photonic emission or the rate of change of intensity of emission are observed compared with the equivalent properties of the uncomplexed component.
REFERENCES:
patent: 4276051 (1981-06-01), Ginsberg et al.
Weeks Ian
Woodhead James S.
Nucker Christine M.
The Welsh National School of Medicine
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