Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1991-12-19
1996-07-23
Kim, Kay K. A.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241431, 4241721, 53038822, 53038875, 53038885, A61K 3900, C07K 1628
Patent
active
055387241
ABSTRACT:
Methods and compositions are described for modulating trafficking of leukocytes to endothelial cells involving the binding of homing receptors and addressins. Particularly, compositions are provided which can inhibit the interaction between the homing receptor and addressin or provide for directing specific molecules associated with diagnosis or treatment, where the molecules bind to the addressins.
REFERENCES:
patent: 5403919 (1995-04-01), Bucher
Bevilacqua, M. P. et al., Fed. Proc (FASEB) 46(3):405, abstract 514 (Mar. 1, 1987), "Indentification of an inducible endothelial-leukocyte adhesion molecule (E-LAM 1) using monoclonal antibodies (Mab)".
Butcher, E. C., Current Topics in Microbiology and Immunology 128:85-121 (1986),"The regulation of lymphocyte traffic".
Kohler, G., et al., Nature 256:495-497 (1975), "Continuous culture of fused cells secreting antibody of predefined specificity".
Paul, W. F. (ed), Fundamental Immunology (1993), pp. 145, 179-184 and 536-537 only, "Lymphoid tissues and organs".
Rothlein, R., et al., J. Immunology 137:1270-1274 (1986), "A human intercellular adhesion molecute (ICAM-1) distinct from LFA-1".
Jalkanen et al., Chemical Abstracts, 107:533 Abstract No. 173820y, (1987). J. Cell Biol.,105(2):983-990. Title: Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glyocoprotein antigen differentuially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.
Jalkanen et al., Biological Abstracts, 83:, Abstract No 34111, (1987). Eur. J. Immunol, 16(10):1195-1202 (1986). Title: A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man.
Jalkanen et al., Biological Abstracts, 33:, Abstract No. 33106700, (1987). Cell Differentiation, 20:120S (1987). Title: An 85-95KDA clycoprotein class is involved in organ-specific homing of human lymphocytes.
Jalkanen et al., Science, 223:556-558 (Aug. 1986). Title: A distant endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium.
E. C. Butcher, 1986 Curr. Topics in Microbiol. and Immunol. pp. 85-121.
E. C. Butcher, et al. 1979 J. Immunol. 123(5): 1996-2003, Lymphocyte adherence.
Berg Ellen L.
Butcher Eugene C.
Streeter Philip R.
Cunningham Thomas
Kim Kay K. A.
Rowland Bertram I.
The Board of Trustees for the Leland Stanford Junior Univ.
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