Process for the production of 2,6-diaminobenzonitrile derivative

Details Process for the production of 2,6-diaminobenzonitrile derivative Process for the production of 2,6-diaminobenzonitrile derivative

1982-07-06

1985-03-12

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544395, 260465E, 546230, 548577, C07C12152, C07D20704

Patent

active

045046603

ABSTRACT:
2,6-Diaminobenzonitriles, useful in the production of N-(2-cyano-3-substituted or unsubstituted amino-phenyl)oxamate and N-(2-cyano-3-substituted or unsubstituted amino-phenyl)tetrazole-5-carboxamide antiallergy and antisecretory agents, are prepared by sequential displacement of the fluoro substituents from 2,6-difluorobenzonitrile with the appropriately substituted amine.

REFERENCES:
patent: 4013647 (1977-03-01), Sellstedt et al.
patent: 4054591 (1977-10-01), Klaubert et al.
patent: 4137325 (1979-01-01), Sellstedt et al.
patent: 4359428 (1982-11-01), Jacobs et al.
Klaubert et al., J. Med. Chem. 24, 742, (1981).
DeVries et al., J. Med. Chem. 19, 946, (1976).
Williams et al., J. Org. Chem. 42, 3414, (1977).
Beck, Tetrahydron 34, 2057, (1978).

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