Vasotocin derivatives

Details Vasotocin derivatives Vasotocin derivatives

1983-12-15

1985-03-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, A61K 3700, C07C10352

Patent

active

045044694

ABSTRACT:
Novel vasotocin derivatives having an inhibitory effect on uterine contractions, pharmaceutical compositions containing these derivatives, and the use thereof in the therapeutical treatment of excessive muscle contractions in the uterus and described. The derivatives differ from vasotocin in that the structure of the original hormone has been modified at positions 1, 2 and, optionally, 4 and/or 8. The vasotocin derivatives thus have the formula ##STR1## wherein Mpa is a 3-mercaptopropionoyl residue (--S--CH.sub.2 --CH.sub.2 --CO--);

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patent: 4367225 (1983-01-01), Manning et al.
patent: 4402942 (1983-09-01), Melin
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