Derivatives of cyclic guanosine-3',5'-monophosphorothioate

Details Derivatives of cyclic guanosine-3',5'-monophosphorothioate Derivatives of cyclic guanosine-3',5'-monophosphorothioate

1995-08-07

1997-04-29

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 19213

Patent

active

056250568

ABSTRACT:
New derivatives of S.sub.P - and R.sub.P -configures cyclic guanosine-3',5'-phosphorothioates and their physiologically and pharmaceutically acceptable salts according to the general formula ##STR1## are cell membrane permeable inhibitors (R.sub.P -isomers) and stimulators (S.sub.P -isomers) of cyclic GMP-dependent protein kinase which are resistant against phosphodiesterase degradation and suitable as ligands for affinity chromatography of cyclic nucleotide-dependent binding proteins.

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