Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1985-12-17
1987-05-26
Helfin, Bernard
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
564 1, 564412, 564496, 568 56, 568639, 568656, 568683, 568936, 568937, 568938, 570127, 570165, C07C 4118, C07C 1718, C07C 7602
Patent
active
046688307
ABSTRACT:
A process for the preparation of compounds containing a difluoromethylene or trifluoromethyl group. A compound containing a carbonyl group, preferbly an acid, acid halide, amide, ketone or any compound containing a perhaloalkylcarbonyl moiety is placed, in anhydrous liquid hydrofluoric acid, in contact with boron trifluoride in a quantity such that the absolute pressure of boron trifluoride in the reaction system is at least one bar for a time sufficient to convert the carbonyl group to a difluormethylene or trifluoromethyl group.
The compounds obtained are useful as synthesis intermediates in the pharmaceutical, plant-protection and dye industries, as anesthetics or as heat-transfer and lubricating fluids.
REFERENCES:
patent: 2567569 (1951-09-01), McBee et al.
patent: 4093665 (1978-06-01), Miller et al.
patent: 4288601 (1981-09-01), Kollonitsch et al.
Sheppard, Journal of Organic Chemistry 29, 1, 1-11, 1964.
Haas et al., Journal of Fluorine Chemistry, 20 (1982), pp. 581-587.
Prober, Jour. Amer. Chem. Soc., 75 (1953), 968-973.
Helfin Bernard
Rhone-Poulenc Specialites Chimiques
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