Nucleoside 5'-alkyl- or alkenylphosphate

Details Nucleoside 5'-alkyl- or alkenylphosphate Nucleoside 5'-alkyl- or alkenylphosphate

1985-05-03

1987-05-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1920

Patent

active

046687785

ABSTRACT:
Nucleoside 5'-alkyl- or alkenyl phosphate compounds represented by the following formula [I] ##STR1## wherein B is a purine base having a substituent or a 5-substituted uracil base, and R.sup.1 is an alkyl or alkenyl group having 14 to 26 carbon atoms, and pharmaceutically acceptable salts thereof are novel derivatives of arabinonucleosides which can have properties suitable for clinical application as antiviral agents, particularly for treating viral hepatitis.

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Mian et al., Synthesis and Biological Activity of 9-B-D-Arabinofuranosyladenine Cyclic 3',5'-Phosphate and 9-B-D-Arabinofuranosylguanine Cyclic 3',5'-Phosphate, J. Medicinal Chem., 17, 259 (1974).
Chemical Abstracts 86: 30033f (1977).
Chemical Abstracts 88: 23342u (1978).

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