Liposome composition for lupus assay

Details Liposome composition for lupus assay Liposome composition for lupus assay

1983-09-26

1987-05-26

Marantz, Sidney

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

264 46, 436507, 436829, 4284022, G01N 33564, B32B 516, B32B 902, B32B 904

Patent

active

046686380

ABSTRACT:
An immunoassay utilizing a novel liposome composition in which there is incorporated a stabilizing or destabilizing component and an antigen. The presence of cognate antibodies in test samples is detected by the alteration of the supramolecular structure of the liposomes resulting in changes in stabilization. Destabilization can be detected, and in certain cases, caused by, the addition of magnesium or calcium ions. Increased stabilization can be detected by the polymerization of bilayer components in response to ultraviolet light. Antibody-antigen interactions at the liposome surface mediate the stabilization/destabilization response.

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patent: 4329331 (1982-05-01), Kallick
patent: 4448765 (1984-05-01), Ash et al.
Schieren, H. et al., Biochem. and Biophys. Res. Comm., 82 (4), pp. 1160-1167 (1978).
Weissmann, G. et al., I: J. Clin. Inves. 53, pp. 536-543 (Feb. 1974).
Weissmann, G. et al., II: Proc. Natl. Acad. Sci. U.S.A. 73(2), pp. 510-514 (Feb. 1976).

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