Insulinotropic hormones and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 12, 514866, 530324, 530308, A61K 3826, A61K 3728, C07K 14605, C07K 1462

Patent

active

059589094

ABSTRACT:
Derivatives of glucagon-like peptide I (GLP-1) and especially GLP-1(7-36) have been found to have insulinotropic activity. The invention pertains to the use of GLP-1(7-36) for the treatment of type II diabetes mellitus.

REFERENCES:
patent: 5118666 (1992-06-01), Habener
patent: 5120712 (1992-06-01), Habener
patent: 5424286 (1995-06-01), Eng
patent: 5545618 (1996-08-01), Buckley et al.
patent: 5574008 (1996-11-01), Johnson et al.
patent: 5614492 (1997-03-01), Habener
patent: 5631224 (1997-05-01), Efendic et al.
Nathan, D.M., et al., "Insulinotropic Action of Glucagon-like 39(Suppl. 1):142A, Abstract No. 568 (May 1990).
Entry entitled "angiotensin," in Seikagaku Jiten (Biochemical Dictionary), First edition, Tokyo Kagaku Dojin, pp. 97-98 (1985).
Entry entitled "diabetes mellitus," in Seikagaku Jiten (Biochemical Dictionary), First edition, Tokyo Kagaku Dojin, pp. 868 (1985).
Albano, J.D.M., et al., "A Sensitive, Precise Radioimmunoassay of Serum Insulin Relying on Charcoal Separation of Bound and Free Hormone Moieties," Acta Endocrinologica 70:487-509 (1972).
Andersen, D.K., et al., "The Insulinotropic Effect of GIP: A Dose Response Comparison and Comparison to Glucagon-Like Peptide-1(7-37) amide (GLP)," Diabetes 39(Suppl. 1):142A, Abstract No. 567 (May 1990).
Drucker, D.J., et al., "Glucagon-like Peptide I Increases Insulin mRNA Levels and Insulin Release in Rat Insulinoma Cells," Abstract No. 602, Programs and Abstract book 68.sup.th Annual Meeting of The Endocrine Society, Jun. 25-27, 1986, Anaheim, CA (Jun. 1986). Disposal In Vivo," Diabetes 39(Suppl. 1):260A, Abstract No. 1005 (May 1990).
Lentz, K.E., et al., "The Amino Acid Composition of Hypertensin II and Its Biochemical Relationship to Hypertensin I," J. Exp. Med. 104: 183-191 (1956).
Minamitake, Y., et al., "Syntheses and Biological Activities of .alpha.-Human Atrial Natriuretic Polypeptide and Its Analogs," in Peptide Chemistry 1984, N. Izumiya, Ed., Protein Research Foundation, Osaka, Japan, pp. 229-234 (1985).
Dialog File 351, Accession No. 87-334950, Derwent WPI English language abstract for JP 1-502746.
Dialog File 351, Accession No. 87-334950, Derwent WPI English language abstract for JP 2583257.
Habener, Joel F. et al., "Complementary DNAs Encoding Precursors of Glucagon and Somatostatin," Biogenetics of Neurohormonal Peptides, Rolf H.ang.kanson et al. Ed., pp. 47-61, Academic Press, London 1985, from The Ferring Symposium on "Biogenetics of Neurohormonal Peptides" Jul. 1-2, 1983, Stockholm, Sweden.
Certificate of Correction for U.S. 5,120,712.
Andrews, P.C. and Ronner, P., "Isolation and Structures of Glucagon and Glucagon-like Peptide from Catfish Pancreas," J. Biol. Chem. 260(7):3910-3914 (Apr. 1985).
Bell, G.I. et al., "Hamster preproglucagon contains the sequence of glucagon and two related peptides," Nature 302:716-718 (1983).
Blackmore, P.F. et al., "Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes," FEBS Lett. 283(1):7-10 (1991).
Creutzfeldt, W. et al., "Entero-Insular Axis 1988," in Diabetes 1988, Larkins, R. et al., eds., Elsevier Science Publishers B.V. (Biomedical Division), pp. 193-203 (1989).
Dobbs, R. et al., "Glucagon: Role in the Hyperglycemia of Diabetes Mellitus," Science 187:544-547 (1975).
Dobs, A.S. et al., "Regulation of Insulin Synthesis in an Insulin-Producing Cell Line (RINm5F): Long-Term Experiments," In Vitro Cell. Dev. Biol. 25(2):112-114 (Feb. 1989).
Drucker, D.J. et al., "Cell-specific Post-translational Processing of Preproglucagon Expressed from a Metallothionein-glucagon Fusion Gene," J. Biol. Chem. 261(21):9637-9643 (1986).
Drucker, D.J. et al., "Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line," Proc. Natl. Acad. Sci. USA 84:3434-3438 (1987).
Fehmann, H.C. et al., "Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line," FEBS Lett. 279(2):335-340 (1991).
Fehmann, H.-C. et al., "Insulinotropic Hormone Glucagon-like Peptide-I(7-37) Stimulation of Proinsulin Gene Expression and Proinsulin Biosynthesis in Insulinoma .beta.TC-1 Cells," Endocrinology 130(1):159-166 (1992).
Ganong, W.F. "Endocrine Functions of the Pancreas & the Regulation of Carbohydrate Metabolism," in Review of Medical Physiology, Lange Medical Publications, Los Altos, CA, pp. 257-276 (1979).
Garcia, S.D. et al., "Biosynthesis of Proinsulin and Insulin in Newborn Rat Pancreas," J. Clin. Invest. 57:230-243 (1976).
Gefel, D. et al., "Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3',5'-Monophosphate Formation," Endocrinology 126(4):2164-2168 (1990).
George, S.K. et al., "Molecular forms of glucagon-like peptides in man," FEBS Lett. 192(2):275-278 (Nov. 1985).
German, M.S. et al., "Regulation of Insulin Gene Expression by Glucose and Calcium in Transfected Primary Islet Cultures," J. Biol. Chem. 265(36):22063-22066 (1990).
Ghiglione, M. et al., "How glucagon-like is glucagon-like peptide-1?," Diabetologia 27:599-600 (1984).
Ghiglione, M. et al., "Plasma Responses of Glucagon-Like Peptide-1 and -2 Immunoreactivities to Oral Glucose in Man," Reg. Peptides 13:101 (Dec. 1985).
Grodsky, G.M. et al., "Pancreatic action of the sulfonylureas," Fed. Proc. 36(13):2714-2719 (1977).
Habener, J.F. et al., "Cell-Specific Alternative Processing of Proglucagon," in Molecular Mechanisms in Secretion, Alfred Benzon Symposium 25, Thorn, N.A. et al., eds., Munksgaard, Copenhagen, pp. 476-492 (1988).
Habener, J.F., "Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors," Molec. Endo. 4(8):1087-1094 (1990).
Hauner, H. et al., "Effects of Gastric Inhibitory Polypeptide on Glucose and Lipid Metabolism of Isolated Rat Adipocytes," Ann. Nutr. Metab. 32:282-288 (1988).
Harrison's Principles of Internal Medicine, 11th Ed., Braunwald, E. et al., eds., McGraw-Hill Book Company, New York, NY, p. 1782 (1987).
Hammonds, P. et al., "Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian virus 40-transformed B cells," FEBS Lett. 213(1):149-154 (1987).
Hammonds, P. et al. "Regulation and specificity of glucose-stimulated insulin gene expression in human islets of Langerhans," FEBS Lett. 223(1):131-137 (1987).
Hausdorff, W.P. et al., "Turning off the signal: desensitization of .beta.-adrenergic receptor function," FASEB J. 4:2881-2889 (1990).
Heinrich, G. et al., "Pre-Proglucagon Messenger Ribonucleic Acid: Nucleotide and Encoded Amino Acid Sequences of the Rat Pancreatic Complementary Deoxyribonucleic Acid," Endocrinology 115(6):2176-2181 (1984).
Hendrick, G.K. et al., "Glucagon-like Peptide-I-(7-37) Suppresses Hyperglycemia in Rats," Metabolism 42(1):1-6 (1993).
Holst, J.J. et al., "Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut," FEBS Lett. 211(2):169-174 (1987).
Hoosein, N.M. and Gurd, R.S., "Human glucagon-like peptides 1 and 2 activate rat brain adenylate cyclase," FEBS Lett. 178(1):83-86 (1984).
Houghten, R.A. et al., "Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Discrete Peptides for Biological, Immunological, and Methodological Studies," BioTechniques 4(6):522-528 (1986).
Jones, I.R. et al., "The effects of gluose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion," Diabetologia 30:707-712 (1987).
Komatsu, R. et al., "Effect of Glucagon-Related Peptides on Rat Endocrine Pancreas," Biomed. Res. 9, Supp. 3:201-206 (1988).
Korman, L.Y. et al., "Characteristics of the Interaction of the Glucagon Receptor, cAMP, and Insulin Secretion in Parent Cells and Clone 5F of a Cultured Rat Insulinoma," Diabetes 34:717-721 (Aug. 1985).
Kreymann, B. et al., "Glucagon-Like Peptide-1 7-36: A Physiological Incretin in Man," Lancet pp. 1300-1304, Dec. 5, 1987.
Lee, C.Q. et al., "Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Insulinotropic hormones and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insulinotropic hormones and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insulinotropic hormones and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-703352

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.