Interdigitated electrode arrays for liposome-enhanced immunoassa

Chemistry: analytical and immunological testing – Involving diffusion or migration of antigen or antibody

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422 56, 422 57, 422 70, 422 8201, 422 8203, 422 98, 422 99, 422110, 4272133, 42721334, 42721335, 436516, 436518, 436530, 436541, 435 3, 435 71, 435 793, 4352877, 435970, 2041827, 204286, 204288, 204290, G01N 33533

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active

059587911

ABSTRACT:
A test device for detecting or determining an analyte in a test solution includes an absorbent material having contact, liposome lysing and electrochemical measurement portions. The contact portion is positioned for contact with and uptake of the test solution. The liposome lysing portion is segregated from the contact portion and has a liposome lysing agent bound thereto. The liposome lysing portion is further either positioned between the contact portion and the electrochemical measurement portion, or partially or completely coincides with the electrochemical measurement portion. The electrochemical measurement portion comprises a first conductor comprising a plurality of fingers disposed on the absorbent material, and a second conductor similarly comprising a plurality of fingers disposed on the absorbent material, where the fingers of the first and second conductors are interdigitated to form an array.

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Durst et al., Development of Liposome-Enhanced Immuno-Biosensing Devices for Field Measurements of Toxic Substances. 2nd Bioelectroanalytical Symposium., 1992.
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