Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or...
Patent
1997-05-02
1999-09-28
Naff, David M.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
424423, 424520, 435 4052, 435174, 435177, 435325, 435366, 530402, 530810, 530812, A01N 102, A61F 200, G01N 130, C12N 1102
Patent
active
059586699
ABSTRACT:
Crosslinking to prepare fixed tissue or to crosslink modification molecules to tissue is carried out with an apparatus and method wherein diffusion through a semipermeable is used to provide a selected molecular weight distribution of oligomers of a crosslinking compound that polymerizes spontaneously in solution to produce oligomers such as glutaraldehyde. The membrane has a molecular weight exclusion limit that prevents oligomers above a certain molecular weight from passing. Tissues treated with the size selected oligomers have improved properties. In the apparatus, the membrane separates a solution containing the crosslinking compound and oligomers from a solution in which crosslinking is carried out. The selected molecular weight distribution of oligomers diffuses through the membrane into the solution where tissue is crosslinked or a beneficial molecule is crosslinked to tissue.
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Ogle Matthew F.
Schroeder Richard F.
Dardi Peter S.
Finucane Hallie A.
Naff David M.
St. Jude Medical Inc.
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