Human protein tyrosine kinase

Details Human protein tyrosine kinase Human protein tyrosine kinase

1998-07-28

1999-09-28

Prouty, Rebecca E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435194, A61K 3846, C12N 912

Patent

active

059584050

ABSTRACT:
The present invention provides a novel protein tyrosine kinase (HPTYK) and polynucleotides which identify and encode HPTYK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPTYK and a method for producing HPTYK. The invention also provides pharmaceutical compositions containing HPTYK or antagonists to HPTYK, and for the use of these compositions in the treatment of diseases associated with the expression of HPTYK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPTYK for the treatment of diseases associated with the expression of HPTYK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding HPTYK or antibodies which specifically bind to HPTYK.

REFERENCES:
patent: 5270458 (1993-12-01), Lemischka
patent: 5367057 (1994-11-01), Lemischka
patent: 5439819 (1995-08-01), Littman et al.
patent: 5447860 (1995-09-01), Ziegler
patent: 5504000 (1996-04-01), Littman et al.
patent: 5573935 (1996-11-01), Beeler et al.
Charbonneau, "1002 Protein Phosphatases," Annu. Rev. Cell Biol., 1992, 8:463-93.
Wilson et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. Elegans," Nature, 368:32-8 (1994) (GI 116679).
Lindberg, R.A. and T. Hunter, "cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk, Family of Protein Kinases", Mol. Cell. Biol., 10: 6316-6324 (1990).
Honegger, A.M. et al ., "A Mutant Epidermal Growth Factor Receptor with Defective Protein Tyrosine Kinase is Unable to Stimulate Proto-Oncogene Expression and DNA Synthesis", Mol. Cell. Biol., 7: 4568-4571 (1987).
Beeler, J.F. et al., "Prokaryotic Expression Cloning of a Novel Human Tyrosine Kinase", Mol. Cell. Biol., 14: 982-988 (1994).

Affiliated with

Also associated with

Rating

Human protein tyrosine kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human protein tyrosine kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human protein tyrosine kinase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-700109