Glycerol derivative and anti-hypertensive agent

Details Glycerol derivative and anti-hypertensive agent Glycerol derivative and anti-hypertensive agent

1990-07-19

1993-02-02

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 82, 514 89, 514 92, 540542, 544157, 546 22, 546 23, 548116, 548413, C07F 958, C07F 960, C07F 96533, C07F 962, A61K 31675

Patent

active

051838117

ABSTRACT:
A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (--(Q).sub.l -- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R.sup.5, R.sup.6 and R.sup.7 is hydrogen, lower alkyl, aryl or aralkyl.

REFERENCES:
patent: 4710579 (1987-12-01), Nojima et al.

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