Prostaglandins E and anti ulcers containing same

Details Prostaglandins E and anti ulcers containing same Prostaglandins E and anti ulcers containing same

1992-08-06

1994-02-08

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560121, 562503, C07G40500, A61K 31557

Patent

active

052848582

ABSTRACT:
The novel 13, 14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-ketoprostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E.
Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.

REFERENCES:
patent: 3836578 (1974-09-01), Samuelson
patent: 4204074 (1980-05-01), Holland
Lee et al, "Effects of Oral Administration of PGE.sub.2 . . . Ulcerations", Prostaglandins, Jan. 1973 vol. 3, No. 1, pp. 29-45.
Anggard, "The Biological Activities of Three Metabolites of Prostaglandin E.sub.1 ", Acta physiol. scand. 1966, 66, pp. 509-510.
European Search Report EP 88 30 0709.

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