Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-03-05
1986-11-04
Marantz, Sidney
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
4351722, 435240, 435241, 435284, 435948, 530399, 935106, 935109, C12P 2100, C12N 1500, C12N 500, C12N 502
Patent
active
046210512
ABSTRACT:
The present invention relates to a process for the production of human Multiplication-Stimulating Activity (hMSA).
More precisely, the invention relates to a process for the mass production of low-cost hMSA, comprising in vivo multiplication of human cells capable of producing said substance, and subsequent in vitro production of hMSA with the multiplied human cells.
hMSA production according to the present invention is much higher, about 2-50-fold higher in terms of hMSA production per cell, than that attained by conventional processes: thus, hMSA can be used in a sufficient amount in the prevention and treatment of human diseases.
REFERENCES:
patent: 3935066 (1976-01-01), Apostolov
patent: 4242460 (1980-12-01), Chick et al.
patent: 4276282 (1981-06-01), Sugimoto et al.
patent: 4285929 (1981-08-01), Sugimoto et al.
patent: 4328207 (1982-05-01), Sugimoto
patent: 4377513 (1983-03-01), Sugimoto et al.
patent: 4383034 (1983-05-01), Sugimoto
patent: 4383035 (1983-05-01), Sugimoto
patent: 4383036 (1983-05-01), Sugimoto
Pontecorvo, G., "Production of Mammalian Somatic Cell Hybrids by Means of Polyethylene Glycol Treatment", Somatic Cell Genetics, vol. 1, No. 4, pp. 397-400 (1975).
Yamanaka, T. et al, "Cultivation of Fused Cells Resulting from Treatment of Cells with HVJ", Biken Journal, vol. 9, 159-175 (1966).
Peterson, J. A. et al, "Expression of Differentiated Functions in Hepatoma Cell Hybrids; Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Fibroblast Hybrids", Proc. Nat. Acad. Sci. U.S.A., vol. 60, #3, 571-575 (1972).
Malawista, S. E. et al, "Expression of Differentiated Functions in Hepatoma Cell Hybrids: High Frequency of Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Lymphoblast Hybrids", Proc. Nat. Acad. Sci. U.S.A., vol. 71, #3, 927-931 (1974).
Nissley, S. P. et al, "Multiplication-Stimulating Activity (MSA): A Somatomedin-like Polypeptide from Cultured Rat Liver Cells", Nat. Cancer Institute Monograph, No. 48, Third Decennial Review Conference, pp. 167-177.
Thompson; J. S. et al, "Heterologous Transplantation of Mouse Tumors into the Newborn Albino Rat", Cancer Research, vol. 20, pp. 1365-1371 (1960).
Zeleznik, Endocrinology, 1979, vol. 105, pp. 156-162.
Pattillo, Hormone Synthesis and Function, in vitro, Growth, Nutrition and Metabolism of Cells in Culture, 1972, Academic Press, N.Y., 225-227.
Bordelon et al,; Human Glycoprotein Hormone Production in Human-Human and Human-Mouse Somatic Cell Hybrids, Chem. Abs., vol. 86, p. 53093.
Lewin, Gene Expression, 1980, Wiley and Sons, N.Y., pp. 259-265.
Bordelon, M. R., et al, Exp. Cell Research, vol. 103, 303-310, (1976).
Owerbach et al, Science, vol. 209, 289-292, Jul. 1980.
DeSantis Patricia L.
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Marantz Sidney
LandOfFree
Process for the production of human multiplication-stimulating a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the production of human multiplication-stimulating a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of human multiplication-stimulating a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-697061