Fluorocarbon emulsions containing amino acid based anti-inflamat

Details Fluorocarbon emulsions containing amino acid based anti-inflamat Fluorocarbon emulsions containing amino acid based anti-inflamat

1989-10-04

1994-02-08

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424530, 514165, 514264, 514332, 514277, 514396, 514400, 514458, 514420, 514557, 514570, A61K 4904, A61K 3140, A61K 31415, A61K 31435

Patent

active

052846458

ABSTRACT:
Disclosed are fluorocarbon emulsions comprising amino acids and substances related to amino acids, such as substituted amino acids or amphoteric groups of amino acid side chains, for example, the imidazolyl group of histidine. Emulsion formulations comprising imidazole and imidazole based drugs possess anti-inflammatory and antipyretic properties which counteract transient inflammatory responses which occur when these emulsions are administered in vivo. Lipid constituents of histidine-containing emulsions are protected against oxidation caused by free radical formation.
Disclosed also are emulsion formulations buffered with amino acids comprising histidine, imidazole, and related compounds that have a buffering capacity sufficient to maintain the emulsion pH within a specified range under storage conditions and protect these emulsions from the endogenous production of acid. Disclosed also is a method of calculation which assists in the selection of an optimum buffer composition and concentration to preserve physiological compatibility and stability of the emulsions within selected pH limits.

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