Use of monosialoganglioside GM, to prevent the development of to

Details Use of monosialoganglioside GM, to prevent the development of to Use of monosialoganglioside GM, to prevent the development of to

1991-06-28

1993-02-02

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514282, A61K 3170, A61K 31715, A61K 3144

Patent

active

051838079

ABSTRACT:
The use of monosialoganglioside GM.sub.1, of its pharmacologically acceptable salts and of its internal ester derivative for the preparation of pharmaceutical compositions for preventing the development in man of tolerance to the analgesic effect of morphine, of chemically correlated opiates, and of methadone and its derivatives is described.

REFERENCES:
patent: 4476119 (1984-10-01), della Valle et al.
patent: 4940694 (1990-07-01), della Valle et al.
patent: 5045532 (1991-09-01), della Valle et al.
patent: 5066496 (1991-11-01), Szabo et al.

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