Human COP9 developmental protein

Details Human COP9 developmental protein Human COP9 developmental protein

1997-03-27

1998-11-03

Scheiner, Toni R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 4353201, 4352523, 435 691, 435 6, C07H 2104, C12N 1563, C12N 121, C12Q 168

Patent

active

058310592

ABSTRACT:
The present invention provides a human COP9 protein (HuCOP9) and polynucleotides which identify and encode HuCOP9. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of HuCOP9, as well as diagnostic assays.

REFERENCES:
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Chamovitz, D.A. et at., "The Novel Components of the Arabidopsis Light Signaling Pathway May Define a Group of General Developmental Regulators Shared by Both Animal and Plants Kingdoms", Cell, 82: 353-354 (1995).
Wei, N. et al., "Arabidopsis COP9 Is a Component of a Novel Signaling Complex Mediating Light Control of Development", Cell, 78: 117-124 (1994).
Jiang, H.P. et al., "Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein", Proc. Natl. Acad. Sci., 89: 7856-7860 (1992).
Wei, N. et al., (Direct Submission), GenBank Sequence Database (Accession 530870), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 530870) Aug. 1994.
Wei, N. et al., (Direct Submission), GenBank Sequence Database (Accession L32874), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 530869) Aug. 1994.
Chamovitz, D.A. et al., (Direct Submission), GenBank Sequence Database (Accession 1730284), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1730284) 12 Dec. 1996.
Chamovitz, D.A. et al., (Direct Submission), GenBank Sequence Database (Accession U51205), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1730283) 13 Dec. 1996.
Chamovitz, DA et al. Cell, 82: 353-354, 1995.
Hillier et al. Genbank Accession Nos. AA 165539, AA 165506, 1995.
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