DNA encoding a novel kidney ATP-dependent potassium channels

Details DNA encoding a novel kidney ATP-dependent potassium channels DNA encoding a novel kidney ATP-dependent potassium channels

1996-09-09

1998-11-03

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4352523, C12N 1512, C12N 1509, C12N 1510, C12N 1511

Patent

active

058310550

ABSTRACT:
The present invention comprises human DNA compositions, including cDNA clones, with full sequences, called, KIRK-2 and KIRK-3, encoding proteins that confer potassium channel activity to membranes or recipient cell lines. The DNA compositions include structural genes coding for the potassium channel proteins, expression and replication plasmids or vectors containing the structural genes and host cells expressing those genes. Methods of screening compounds for potassium channel modulating activity are also described.

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