Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1986-02-18
1998-11-03
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530412, 530413, 530416, 530417, 530418, 530419, 530420, 930141, 424 852, 435 6952, C07K 1452, A61K 3820
Patent
active
058310223
ABSTRACT:
A process for the production of essentially homogeneous soluble, stable, endotoxin free human recombinant interleukin-1.alpha. of enhanced specific activity is described. The process involves breaking transformed microbial cells containing expressed human interleukin-1.alpha. and separating the soluble supernatant from the insoluble cell components and then passing the supernatant through gel chromatography and ion-exchange chromatography steps.
REFERENCES:
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Buchholz Briana C.
Draper Garnette D.
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
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