Pyranoindole and tetrahydrocarbazole inhibitors of COX-2

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548449, A61K 3140, C07D20986

Patent

active

058309110

ABSTRACT:
This invention provides compounds of formula I having the structure ##STR1## wherein R is (CH.sub.2).sub.n COOR.sup.4 ;

REFERENCES:
Huang et al, Exp. Opin. Invest. Drugs, Cyclooxygenase and 5-lipoxygenase inhibitors for the prevention and treatment of cancer, (1995) 4(3):243-249.
Rogers et al., Neurology, Clinical trial of indomethacin in Alzheimer's disease, (1993) 43:1609-1611.
Sano et al., Cancer Res., Expression of Cyclooxygenase-1 and -2 in Human Colorectal Cancer, (1995) 55:3785-3789.

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