Compositions and methods for the treatment of arterial chlamydia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514171, 514210, 514332, A01N 4304

Patent

active

058308741

ABSTRACT:
Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial granuloma. Therapeutic composition for treating arterial chlamydial granulomatous disease, including an anti-Chlamydia pneumoniae agent and a granuloma inhibitor.

REFERENCES:
patent: 5008186 (1991-04-01), Grayston et al.
patent: 5229381 (1993-07-01), Doherty et al.
patent: 5354866 (1994-10-01), Kempf et al.
Grayston, JT, Kuo CC, Campbell LA, Wang SP. Chlamydia pneumoniae sp. nov. for Chlamydia sp. strain TWAR. Int. J.Syst. Bacteriol. 1989; 39: 88-90.
Chi EY, Kuo, CC, Grayston T.J. Unique ultrastructure in Elementary Body of Chlamydia sp. strain TWAR. Int. J. Syst. Bacteriol. 1987; 169:3757-3673.
Grayston TJ, Campbell LA, Kuo CC, Mordhorst CH, Saikku P, Thom DH, Wang SP. A New Respiratory Tract Pathogen. Chlamydia pneumoniae Strain TWAR. J. Infect. Dis. 1990; 161:618-625.
Saikku P, Mattila K, Nieminen MS, Huttunen JK, Leinonen M, Ekman MR, Makela PH, Valtonen V. Serological evidence of an association of a novel Chlamydia, TWAR with chronic Coronary Heart Disease and Acute Myocardial Infarction. Lancet, 1988; 2: 983-985.
Thom DH, Wang SP, Grayston JT, Siscovick DS, Steward DK, Kronmal RA, Weiss NS. Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease. Arteriosclerosis and Thrombosis 1991; 11: 547-551.
Kuo CC, Chen HH, Wang SP, Grayston T. Identifiction of new Group of Chlamydia psittaci Strains called TWAR. J. Clin. Microbiol., 1986; 24: 1034-2125.
Guyton JR. Klemp KF. The lipid Rich Core Region of Human Atherosclerotic Fibrous Plaques. Am. T. Pathol., 1989; 134: 705-717.
Sutton GC, Demakis JA, Anderson TO, Morrissey RA. Serologic evidence of a sporadic outbreak in Illinois of infection by Chlamydia (psittacosis-LGV agent) in patients with primary myocardial disease and respiratory disease. Am Heart J 1971;p 81: 597-607.
Grayston TT, Mordhorst CH, Wang SP. Childhood myocarditis associated with Chlamydia tracomatis infection. JAMA 1981; 246: 2823-2827.
Jones RB, Priest JB, Kuo CC. Subacute chlamydial endocarditis JAMA 1982; 247:655-658.
Marrie TJ, Harczy M, Mann OE, Landymore RW, Raza A, Wang SP, Grayston JT. Culture-negative endocarditis probably due to Chlamydia pneumoniae. J Infect Dis 1990; 161: 127-129.
Benditt EP, Barrett T, McDougall JK. Viruses in the etiology of atherosclerosis. Proc. Natl. Acad. Sci. USA. 1983; 80: 6386-6389.
Saikku P, Leinonen M, Tenkanen L, Linnanmaki E, Ekman MR, Manninen V, Manttari M, Frick MH, Huttunen JK, Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann Int Med 1992;116:273-278.
Campbell LA, Perez-Melgosa M, Hamilton DJ, Kuo CC, Grayston JT, Detection of Chlamydia pneumoniae by polymerase chain reaction. J Clin Microbiol 1992;30:434-439.
Kuo CC, Grayston JT, A sensitive cell line, HL cells, for isolation and propagation of Chlamydia pneumoniae strain TWAR. J Infect Dis 1990;162:755-758.
Kuo CC, Grayston JT, Factors affecting viability and growth in HeLa 229 cells of Chlamydia sp. strain TWAR. J. Clin. Microbiol. 1988;26:812-815.
Kuo CC, Cultures of Chlamydia trachomatis in mouse peritoneal macrophages: Factors affecting organism growth. Infect. Immun. 1978; 20:439-445.
Yong, EC, Chi EY, Kuo CC, Differential antimicrobial activity of human mononuclear phagocytes against the human biovars of Chlamydia trachomatis. J. Immunol 1987; 139:1297-1302.
Chen WJ, Kuo CC, A mouse model of pneumonitis induced by Chlamydia trachomatis: Morphologic, microbiologic and immunologic studies. Am J Pathol 1980;100:365-377.
Rothermel CD, Schachter J, Lavrich P, Lipsitz EC, Francus T, Chlamydia trachomatis-induced production interleukin-1 by human monocytes. Infect Immun 1989;57:2705-2711.
Kuo CC, Grayston JT, In vitro drug susceptibility of Chlamydia sp. strain TWAR. Antimicrob Agents Chemother 1988;32:257-258.
Lipsky BA, Tack KJ, Wang SP, Kuo CC, Grayston JT, Ofloxacin treatment of a Chlamydia pneumoniae (strain TWAR) lower respiratory tract infections. Am J Med 1990;89:722-724.
Grayston, J.T., Kuo, C.C., Wang, S.P., Altman, J. A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. New. Engl. J. Med. 1986; 315: 161-168.
Kleemola, M., Saikku, P., Visakorpi, R., Wang, S.P. Epidemics of pneumonia caused by TWAR, A new Chlamydia organism, in military trainees in Finland. J. Infect. Dis. 1988; 157: 230-236.
Campbell, L.A., Kuo, C.C., Thissen, R.W. and Grayston, J.T. Isolation of a gene encoding a Chlamydia sp. strain TWAR protein that is recognized during infection of humans. Infect. Immun. 1989; 57:71-75.
Ladany, S., Black, C.M., Farshy, C.E., Ossewaarde, J.M. and Barnes, R.C. Enzyme immunoassay to determine exposure to Chlamydia pneumoniae (Strain TWAR). J. Clin. Microbiol. 1989; 27:2778-2783.
Fu, Y., Baumann, M., Kosma, P., Brade, L. and Brade, H. A synthetic glycoconjugate representing the genus-specific epitope of Chlamydial lipopolysaccharide exhibits the same specificity as its natural counterpart. Infect. Immun. 1992; 60: 1314-1321.
Stuart, E.S., Wyrick, P.B., Choong, J., Stoler, S.B., MacDonald, A.B. Examination of chlamydial glycolipid with monoclonal antibodies: cellular distribution and epitope binding. Immunol. 1991; 74: 740-747.
Karimi, S.T., Schloemer, R.H. and Wilde, C.E. Accumulation of Chlamydial lipopolysaccharide antigen in the plasma membranes of infected cells. Infect. Immun. 1989; 57: 1780-1785.
Brade, L., Hoist, O., Kosma, P., Zhang, Y-X., Paulsen, H., Krausse, R., and Brade, H. Characterization of murine monoclonal and murine, rabbit, and human polyclonal antibodies against Chlamydial lipopolysaccharide. Infect. Immun. 1990; 58: 205-213.
Shor, A., Kuo, C.C., Patton, D.L., Fukushi, H., and Campbell, L.A. Detection of Chlamydia pneumoniae in the coronary artery atheroma plaque. 1992. Amer. Soc. Microbiol. Abstract #D-67, p. 107, Gereral Meeting, New Orleans, La.
Bobo, L., Coutlee, F., Yolken, R.H., Quinn, T., and Viscidi, R.P. Diagnosis of Chlamydia trachomatis cervical infection by detection of amplified DNA with an enzyme immunoassay. J. Clin. Microbiol. 1990, 28:1968-1973.
Holland, S.M., Taylor, H.R., Gaydos, C.A., Kappus, E.W. and Quinn, T.C. Experimental infection with Chlamydia pneumoniae in nonhuman primates. Infect. Immun. 1990, 58:593-597.
Bell, T.A., Kuo, C.-C., Wang, S.P. and Grayston, J.T. Experimental infection of baboons (Papio cynocephalus anubis) with Chlamydia pneumoniae strain `TWAR`. J. Infection 1989, 19: 47-49.
Koskenvuo, M. and Romanov, K., Lancet 1989, i: 158; and, Saikku, P., Leinonen, M., Mattila, K., Ekman, M.R., Nieminen, M.S., Makela, P.H., Huttunen, J.K., and Valtonen, V., lancet 1989, i: 158.
Leinonen, M., Linnanmaki, E., Mattila, K., Nieminen, M.S., Valtonen, V., Leirisalo-Repo, M., and Saikku, P. Circulating immune complexes containing Chlamydial lipopolysaccharide in acut myocardial infarction. Microbial Pathogenesis 1990, 9:67-73.
Thom, D.H., Wang, S-P., Grayston, J.T., Siscovick, D.S., Stewart, D.K., Weiss, N.S., and Kronmal, R.A. The association between Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease. Circulation 1991, 83:P 736.
Thom, D.H., Grayston, J.T., Wang, S-P., Kuo, C.C. and Altman, J. Chlamydia pneumoniae strain TWAR, Mycoplasma pneumoniae, and viral infections in acute respiratory disease in a Univeristy student health clinic population. Amer. J. Epidemiol. 1990, 132: 248-256.
Nevill, Woolf, "Pathology of Atherosclerosis", Butterworths Scientific Co. Ltd. pp. 1-2 and 47-65 91982).
Haust, M.D. The morphogenesis and fate of potential and early atherosclerotic lesions in man. Human Pathology 2: 1-29 (1971).
Kuo, C-C., E.Y. Chi, and J.T. Grayston. Ultrastructural study of entry of Chlamydia strain TWAR into HeLa cells. Infect. Immun. 56: 1668-1672 (1988).
Bocan, T.M.A. and J.R. Guyton. Human aortic fibrolipid lesions: Progenitor lesions for fibrous plaques, exhnibiting early formation of the cholesterol-rich core. Am. J. pathol.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions and methods for the treatment of arterial chlamydia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for the treatment of arterial chlamydia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for the treatment of arterial chlamydia will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-689240

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.