Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1996-05-23
1998-11-03
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435219, 435 23, 4352523, 43525411, 4353201, 435325, 514 2, 514 1, 536 232, 5303871, 5303881, 530300, 530351, C12N 964, C12N 100, C12N 510, C12Q 137
Patent
active
058307427
ABSTRACT:
A metalloprotease that converts TNF-.alpha. from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
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Hell et al. Cleavage of tumor necrosis factor-alpha by legionella exoprotease. Acta Pathol. Microbiol. Immunol. Scand. 101(2): 120-126, 1993.
Black, R. et al., "A metalloproteinase disintegrin that releases tumour-necrosis factor-.alpha. from cells", Nature 385: 729-732, 1997.
Moss, M., et al., "Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-.alpha.", Nature 385: 733-736 1997.
Black Roy A.
Cerretti Douglas P.
March Carl J.
Rauch Charles
Bugaisky Gabriele E.
Immunex Corporation
Malaska Stephen L.
Patterson Jr. Charles L.
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