Treatment of osteoporosis and metabolic bone disorders with nitr

Details Treatment of osteoporosis and metabolic bone disorders with nitr Treatment of osteoporosis and metabolic bone disorders with nitr

1996-03-19

1999-04-27

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing compound doai

514108, A61K 3104, A61K 3166

Patent

active

058980385

ABSTRACT:
Primary and secondary osteoporosis in a female or a male mammal is treated by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally; in further combination with one or more of an estrogen, a progestin, an anabolic steroid. Nitric oxide substrate or donor also can be combined with one or more of other medications acting on bone, such as bisphosphonate, calcitonin, fluoride, androgen and other novel therapeutic agents. Either nitric oxide donor or substrate by itself or combination with other medications as described above can be used in both women and men, (preferably human) for prevention and treatment of osteoporosis and other metabolic bone disorders.

REFERENCES:
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Wimalawansa et al., "Nitric Oxide Donor Alleviates Ovariectomy-Induced Bone Loss," Bone, 18(4):301-304, 1996.
Wimalawansa et al., "Replacement Therapy with Nitric Oxide or Nitric Oxide Dornor In Vivo, Maintains the Bone Mass in Rats After Ovariectomy," World congress on Osteopororis, Abstract No. PTU 759, Amsterdam, May 18-23, 1996.
Wimalawansa, "Steroid-Induced Osteoporosis can be Prevented with Nitric Oxide," American Society for Bone and Mineral Research, Sep. 7-11, 1996.
Yallampalli et al., "Calcitonin Gene-Related Peptide Reverses the Hypertension and Significantly Decreases the Fetal Mortality in Pre-Eclampsia Rats Induced by N.sup.G -Nitro-L-Arginine Methyl Ester," Human Reproduction, 11(4):895-899, 1996.

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