Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1995-03-27
1998-09-29
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
435 691, 4351723, 4353201, 536 231, 536 232, 536 235, 536 241, C12N 1585, C12N 1511, C07H 2104
Patent
active
058145176
ABSTRACT:
The present invention provides oligonucleotide sequences comprising DNA regulatory elements of the general sequence TTN.sub.X AA that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonist and antagonists of gene transcription.
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Lamb I. Peter
Seidel H. Martin
Chambers Jasemine C.
Elmer J. Scott
Ligand Pharmaceuticals Inc.
Priebe Scott D.
Respess William L.
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